2010 ECM Prague Open – Singles

The women's singles of the 2010 ECM Prague Open tournament was played on clay in Prague, Czech Republic.

Sybille Bammer was the defending champion, but chose not to participate.

Ágnes Szávay defeated Barbora Záhlavová-Strýcová in the final (6–2, 1–6, 6–2).

Seeds
• # 🇨🇿 Lucie Šafářová (second round, withdrew due to hamstring muscle injury)

• # 🇷🇴 Alexandra Dulgheru (second round, withdrew due to knee injury)

• # Timea Bacsinszky (first round)

• # 🇨🇿 Klára Zakopalová (withdrew due to acute gastroenteritis)

• # 🇪🇸 Anabel Medina Garrigues (quarterfinals)

• # 🇦🇷 Gisela Dulko (withdrew due to tonsillitis)

• # 🇭🇺 Ágnes Szávay (champion)

• # 🇨🇿 Barbora Záhlavová-Strýcová (final)