2010 Estoril Open – Women's singles

Yanina Wickmayer was the defending champion, but she chose to play in Rome rather than defend 2009 title here.

Anastasija Sevastova won her first WTA singles title, defeating Arantxa Parra Santonja in the final 6–2, 7–5.

Seeds
• # 🇭🇺 Ágnes Szávay (first round)

• # 🇷🇴 Sorana Cîrstea (semifinals)

• # 🇨🇦 Aleksandra Wozniak (first round)

• # 🇪🇸 Anabel Medina Garrigues (quarterfinals)

• # 🇭🇺 Melinda Czink (first round)

• # 🇸🇰 Magdaléna Rybáriková (first round)

• # 🇨🇳 Peng Shuai (semifinals)

• # 🇦🇹 Sybille Bammer (first round)