2010 FINA World Swimming Championships (25 m) – Men's 400 metre individual medley

The Men's 400 Individual Medley (or "I.M.") at the 10th FINA World Swimming Championships (25m) was swum on 16 December 2010 in Dubai, United Arab Emirates. 35 individuals swam in the Preliminary heats of the event in the morning, with the top-8 finishers advancing on the Final that evening.

At the start of the event, the existing World (WR) and Championship records (CR) were:

The following records were established during the competition: