2010 FINA World Swimming Championships (25 m) – Women's 100 metre breaststroke

The Women's 100 Breaststroke at the 2010 FINA World Swimming Championships (25m) was swum 17–18 December in Dubai, United Arab Emirates. Preliminary heats and semifinals were on 17 December, the final on 18 December.

55 swimmers swam the race. At the start of the event, the existing World (WR) and Championship records (CR) were:
 * WR: 1:02.70, 🇺🇸 Rebecca Soni, (Manchester, UK, 19 December 2009)
 * CR: 1:04.22, 🇺🇸 Jessica Hardy, (Manchester 2008)

The following records were established during the competition:

Semifinals
Semifinal 1

Semifinal 2