2010 FINA World Swimming Championships (25 m) – Women's 100 metre individual medley

The Women's 100 Individual Medley (or I.M.) at the 10th FINA World Swimming Championships (25m) took place 16–17 December 2010 in Dubai, United Arab Emirates. The preliminary heats and semifinals were swum on 16 December; the final on 17 December.

66 individuals swam the event.

Records
Prior to the competition, the existing world and championship records were as follows.

The following records were established during the competition:

Semifinals
Semifinal 1

Semifinal 2