2010 Family Circle Cup – Singles

Sabine Lisicki was the defending champion but chose not to compete due to a left ankle injury.

Samantha Stosur won the title, defeating Vera Zvonareva in the final 6–0, 6–3.

Seeds
The top eight seeds receive a bye into the second round. • # Caroline Wozniacki (semifinals, retired due to sprained ankle)

• # 🇷🇸 Jelena Janković (quarterfinals)

• # 🇧🇾 Victoria Azarenka (second round, retired due to a left thigh strain)

• # 🇦🇺 Samantha Stosur (champion)

• # 🇫🇷 Marion Bartoli (second round, retired due to dizziness and stomach upset)

• # 🇷🇺 Nadia Petrova (quarterfinals)

• # 🇷🇺 Vera Zvonareva (final)

• # 🇸🇰 Daniela Hantuchová (semifinals)

• # 🇺🇦 Alona Bondarenko (third round)

• # 🇷🇺 Elena Vesnina (third round)

• # 🇫🇷 Virginie Razzano (first round)

• # 🇨🇦 Aleksandra Wozniak (third round)

• # 🇺🇸 Melanie Oudin (quarterfinals)

• # 🇷🇺 Vera Dushevina (third round)

• # 🇭🇺 Melinda Czink (first round)

• # Patty Schnyder (third round)