2010 French Open – Mixed doubles

Liezel Huber and Bob Bryan were the defending champions, but Bryan chose to not compete this year in mixed doubles.

Huber partnered up with Mahesh Bhupathi, but they lost in the first round against Chan Yung-jan and Eric Butorac.

Katarina Srebotnik and Nenad Zimonjić won in the final 4–6, 7–6(7–5), [11–9], against Yaroslava Shvedova and Julian Knowle.

Seeds
• # 🇺🇸 Liezel Huber / 🇮🇳 Mahesh Bhupathi (first round)

• # Cara Black / 🇮🇳 Leander Paes (quarterfinals)

• # 🇪🇸 Nuria Llagostera Vives / 🇦🇹 Oliver Marach (semifinals)

• # 🇺🇸 Bethanie Mattek-Sands / Mark Knowles (first round)

• # 🇷🇺 Alisa Kleybanova / 🇧🇾 Max Mirnyi (quarterfinals)

• # Katarina Srebotnik / 🇷🇸 Nenad Zimonjić (champions)

• # 🇺🇸 Lisa Raymond / Wesley Moodie (first round)

• # 🇨🇳 Yan Zi / 🇵🇱 Mariusz Fyrstenberg (first round)