2010 Hall of Fame Tennis Championships – Singles

Rajeev Ram was the champion in 2009; however, he lost to qualifier Raven Klaasen in the second round. Mardy Fish defeated Olivier Rochus in the final 5–7, 6–3, 6–4.

Seeds
• # 🇺🇸 Sam Querrey (second round)

• # 🇨🇴 Santiago Giraldo (second round)

• # 🇨🇴 Alejandro Falla (first round)

• # 🇧🇪 Olivier Rochus (final)

• # 🇺🇸 Mardy Fish (champion)

• # 🇸🇰 Karol Beck (first round)

• # 🇺🇸 Rajeev Ram (second round)

• # 🇺🇸 Taylor Dent (first round)