2010 Heineken Open – Singles

Juan Martín del Potro was the defending champion, but chose not to compete.

John Isner won in the final, 6–3, 5–7, 7–6(7–2), against Arnaud Clément.

Seeds
The top four seeds receive a bye to the second round.

• # 🇪🇸 Tommy Robredo (quarterfinals)

• # 🇪🇸 David Ferrer (second round)

• # 🇪🇸 Juan Carlos Ferrero (second round, retired because of a right ankle sprain)

• # 🇪🇸 Nicolás Almagro (second round)

• # 🇩🇪 Philipp Kohlschreiber (semifinals)

• # 🇦🇹 Jürgen Melzer (quarterfinals)

• # 🇦🇷 Juan Mónaco (second round)

• # 🇪🇸 Albert Montañés (semifinals)

Qualifying
All seeded players received a bye into the second round, and all players playing in the fourth qualifier received a bye into the second round.

Seeds
• # 🇮🇹 Paolo Lorenzi (qualified)

• # Michael Lammer (qualified)

• # 🇪🇸 Íñigo Cervantes (qualifying competition, lucky loser)

• # 🇨🇿 Jan Minář (second round)

• # 🇬🇧 Daniel Evans (qualified)

• # 🇪🇸 Carles Poch Gradin (qualifying competition)

• # 🇪🇸 Guillermo Olaso (qualifying competition)

• # 🇪🇸 Pedro Clar-Rossello (second round)

Qualifiers
• # 🇮🇹 Paolo Lorenzi

• # Michael Lammer

• # 🇦🇺 James Lemke

• # 🇬🇧 Daniel Evans