2010 Internazionali Femminili di Palermo

The 2010 Internazionali Femminili di Palermo was a women's tennis tournament played on outdoor clay courts. It was the 23rd edition of the Internazionali Femminili di Palermo, part of the WTA International tournaments of the 2010 WTA Tour. It took place in Palermo, Italy, from 12 July until 18 July 2010.

Other entrants
The following players received wildcards into the singles main draw
 * 🇮🇹 Anna Floris
 * 🇮🇹 Romina Oprandi
 * 🇮🇹 Flavia Pennetta

The following players received entry from the qualifying draw:
 * 🇮🇹 Martina Caregaro
 * 🇮🇹 Corinna Dentoni
 * 🇪🇸 Nuria Llagostera Vives
 * Mirjana Lučić
 * 🇷🇺 Anastasia Pivovarova (as a Lucky loser)

Singles
🇪🇪 Kaia Kanepi defeated 🇮🇹 Flavia Pennetta, 6–4, 6–3
 * It was Kanepi's only singles title of the year and the first of her career.

Doubles
🇮🇹 Alberta Brianti / 🇮🇹 Sara Errani defeated 🇺🇸 Jill Craybas / 🇩🇪 Julia Görges 6–4, 6–1