2010 Italian Open – Men's singles

Defending champion Rafael Nadal defeated David Ferrer in the final, 7–5, 6–2 to win the men's singles tennis title at the 2010 Italian Open. It was his record-extending fifth Italian Open title.

Seeds
The top eight seeds receive a bye into the second round. • # Roger Federer (second round)

• # 🇷🇸 Novak Djokovic (quarterfinals)

• # 🇪🇸 Rafael Nadal (champion)

• # 🇬🇧 Andy Murray (third round)

• # 🇸🇪 Robin Söderling (third round)

• # 🇪🇸 Fernando Verdasco (semifinals)

• # 🇫🇷 Jo-Wilfried Tsonga (quarterfinals)

• # Marin Čilić (second round)

• # 🇷🇺 Mikhail Youzhny (first round)

• # 🇨🇿 Tomáš Berdych (second round)

• # Ivan Ljubičić (third round, retired due to side strain)

• # 🇪🇸 Juan Carlos Ferrero (first round)

• # 🇪🇸 David Ferrer (final)

• # 🇺🇸 John Isner (second round)

• # 🇺🇸 Sam Querrey (first round)

• # 🇦🇷 Juan Mónaco (second round)

Seeds
• # 🇦🇷 Juan Ignacio Chela (qualified)

• # 🇫🇷 Michaël Llodra (qualified)

• # 🇨🇴 Alejandro Falla (first round)

• # 🇩🇪 Simon Greul (qualifying competition, lucky loser)

• # 🇦🇷 Leonardo Mayer (qualified)

• # 🇫🇮 Jarkko Nieminen (qualifying competition)

• # 🇺🇦 Alexandr Dolgopolov (qualifying competition)

• # 🇺🇦 Sergiy Stakhovsky (first round)

• # 🇺🇸 Michael Russell (first round)

• # 🇦🇺 Peter Luczak (qualified)

• # 🇰🇿 Andrey Golubev (qualifying competition)

• # 🇨🇴 Santiago Giraldo (qualified)

• # 🇺🇿 Denis Istomin (first round)

• # 🇨🇿 Jan Hájek (qualified)

Qualifiers
• # 🇦🇷 Juan Ignacio Chela

• # 🇫🇷 Michaël Llodra

• # 🇪🇸 Marcel Granollers

• # 🇦🇺 Peter Luczak

• # 🇦🇷 Leonardo Mayer

• # 🇨🇴 Santiago Giraldo

• # 🇨🇿 Jan Hájek

Lucky losers
• # 🇩🇪 Simon Greul