2010 Italian Open – Women's doubles

Hsieh Su-wei and Peng Shuai were the defending champions, but Hsieh chose not to compete this year and Peng chose to compete in Estoril instead.

6th-seeded Gisela Dulko and Flavia Pennetta won in the final 6–4, 6–2, against 2nd-seeded Nuria Llagostera Vives and María José Martínez Sánchez.

Seeds
The top four seeds received a bye into the second round. • # 🇺🇸 Liezel Huber / 🇷🇺 Nadia Petrova (semifinals)

• # 🇪🇸 Nuria Llagostera Vives / 🇪🇸 María José Martínez Sánchez (finals)

• # Cara Black / 🇷🇺 Elena Vesnina (second round, retired)

• # 🇺🇸 Lisa Raymond / 🇦🇺 Rennae Stubbs (semifinals)

• # 🇺🇸 Bethanie Mattek-Sands / 🇨🇳 Yan Zi (quarterfinals)

• # 🇦🇷 Gisela Dulko / 🇮🇹 Flavia Pennetta (champions)

• # 🇨🇿 Květa Peschke / Katarina Srebotnik (second round)

• # Chuang Chia-jung / 🇧🇾 Olga Govortsova (second round)