2010 JSM Challenger of Champaign–Urbana – Singles

Michael Russell was the defending champion, but decided not to participate. Alex Bogomolov Jr. defeated Amer Delić 5–7, 7–6(7), 6–3 in the final to win the tournament.

Seeds
• # 🇯🇵 Kei Nishikori (second round)

• # 🇦🇺 Peter Luczak (quarterfinals)

• # 🇦🇺 Carsten Ball (first round)

• # Izak van der Merwe (first round)

• # 🇺🇸 Bobby Reynolds (semifinals)

• # 🇺🇸 Alex Bogomolov Jr. (champion)

• # 🇺🇸 Lester Cook (first round)

• # 🇪🇨 Giovanni Lapentti (first round)