2010 Kremlin Cup – Women's singles

Francesca Schiavone was the defending champion, but chose not to participate this year.

Victoria Azarenka won the title, defeating Maria Kirilenko in the final 6–3, 6–4.

Seeds
The top two seeds receive a bye into the second round. • # 🇷🇸 Jelena Janković (second round)

• # 🇧🇾 Victoria Azarenka (champion)

• # 🇨🇳 Li Na (first round)

• # 🇷🇺 Anastasia Pavlyuchenkova (first round)

• # 🇮🇹 Flavia Pennetta (first round)

• # 🇷🇺 Maria Kirilenko (final)

• # 🇷🇺 Alisa Kleybanova (quarterfinals)

• # 🇪🇸 María José Martínez Sánchez (semifinals)