2010 Legg Mason Tennis Classic – Singles

Juan Martín del Potro was the defending champion, but didn't participate due to a wrist injury.

David Nalbandian, ranked 117th, defeated Marcos Baghdatis 6–2, 7–6(7–4) in the final.

Seeds
All seeds received a bye into the second round. • # 🇨🇿 Tomáš Berdych (quarterfinals)

• # 🇺🇸 Andy Roddick (third round)

• # 🇪🇸 Fernando Verdasco (quarterfinals)

• # Marin Čilić (semifinals)

• # 🇺🇸 John Isner (third round)

• # 🇺🇸 Sam Querrey (second round)

• # Stanislas Wawrinka (second round)

• # 🇨🇾 Marcos Baghdatis (final)

• # Ernests Gulbis (second round, retired due to back injury)

• # 🇨🇿 Radek Štěpánek (second round)

• # 🇦🇺 Lleyton Hewitt (second round, retired due to right calf injury)

• # 🇫🇷 Julien Benneteau (second round)

• # 🇫🇷 Gilles Simon (quarterfinals)

• # 🇫🇷 Michaël Llodra (second round)

• # 🇺🇸 Mardy Fish (third round)

• # 🇰🇿 Andrey Golubev (third round)

Seeds
• # Kevin Anderson (qualifying competition)

• # 🇺🇸 Michael Russell (qualifying competition)

• # 🇦🇷 Brian Dabul (qualified)

• # 🇺🇸 Donald Young (qualifying competition)

• # 🇮🇳 Somdev Devvarman (qualifying competition)

• # 🇺🇸 Ryan Sweeting (qualified)

• # 🇷🇺 Igor Kunitsyn (qualified)

• # Grega Žemlja (qualified)

• # 🇨🇴 Carlos Salamanca (first round)

• # 🇺🇸 Kevin Kim (qualified)

• # Igor Sijsling (qualifying competition)

• # 🇯🇵 Kei Nishikori (qualified)

Qualifiers
• # 🇯🇵 Kei Nishikori

• # 🇷🇺 Igor Kunitsyn

• # 🇦🇷 Brian Dabul

• # Grega Žemlja

• # 🇺🇸 Kevin Kim

• # 🇺🇸 Ryan Sweeting