2010 MasterCard Tennis Cup – Singles

Horacio Zeballos won last year's edition, but decided not to participate this year.

Izak van der Merwe won the singles title, defeating Ricardo Mello 7–6(6), 6–3 in the finals.

Seeds
• # 🇧🇷 Ricardo Mello (final)

• # 🇫🇷 David Guez (first round)

• # 🇧🇷 Marcos Daniel (first round)

• # 🇫🇷 Josselin Ouanna (first round)

• # 🇧🇷 João Souza (second round)

• # 🇧🇷 Júlio Silva (first round)

• # 🇧🇷 Caio Zampieri (quarterfinals)

• # 🇫🇷 Charles-Antoine Brézac (first round)