2010 Medibank International Sydney – Men's singles

David Nalbandian was the defending champion, but chose not to participate this year.

In the final, Marcos Baghdatis defeated Richard Gasquet, 6–4, 7–6(7–2).

It was his first maiden ATP Tour title.

Seeds
The top four seeds receive a bye to the second round. • # 🇫🇷 Gaël Monfils (withdrew due to a shoulder injury)

• # 🇨🇿 Tomáš Berdych (second round)

• # Stanislas Wawrinka (withdrew due to a neck injury)

• # 🇦🇺 Lleyton Hewitt (quarterfinals)

• # 🇺🇸 Sam Querrey (first round)

• # 🇷🇸 Viktor Troicki (second round)

• # 🇷🇺 Igor Andreev (first round)

• # 🇩🇪 Benjamin Becker (second round)

Seeds
• # 🇫🇷 Arnaud Clément (withdrew)

• # 🇫🇷 Florent Serra (moved into main draw)

• # 🇫🇷 Michaël Llodra (moved into main draw)

• # Fred Gil (qualified)

• # 🇪🇸 Daniel Gimeno Traver (qualifying competition, lucky loser)

• # 🇦🇷 Juan Ignacio Chela (qualified)

• # 🇦🇷 Leonardo Mayer (qualified)

• # 🇺🇸 Taylor Dent (qualifying competition, lucky loser)

Qualifiers
• # 🇦🇷 Juan Ignacio Chela

• # 🇦🇺 Marinko Matosevic

• # 🇦🇷 Leonardo Mayer

• # Fred Gil

Lucky loser
• # 🇪🇸 Daniel Gimeno Traver

• # 🇺🇸 Taylor Dent