2010 Medibank International Sydney – Women's singles

In a rematch of last year's semifinal, Elena Dementieva successfully defended her title, beating world No. 1 Serena Williams in the final 6–3, 6–2.

Seeds
The top two seeds receive a bye to the second round.


 * 1) 🇺🇸 Serena Williams (final)
 * 2) 🇷🇺 Dinara Safina (quarterfinals)
 * 3) 🇷🇺 Svetlana Kuznetsova (second round)
 * 4)  Caroline Wozniacki (first round)
 * 5) 🇷🇺 Elena Dementieva (champion)
 * 6) 🇧🇾 Victoria Azarenka (semifinals)
 * 7) 🇷🇸 Jelena Janković (first round)
 * 8) 🇷🇺 Vera Zvonareva (first round, retired due to right ankle injury)