2010 Monterrey Open – Singles

Marion Bartoli was the defending champion; however, she didn't take part in these championships this year. Anastasia Pavlyuchenkova won her first WTA singles title, defeating Daniela Hantuchová in the final 1–6, 6–1, 6–0.

Seeds
• # 🇷🇸 Jelena Janković (first round)

• # 🇸🇰 Daniela Hantuchová (final)

• # 🇷🇺 Anastasia Pavlyuchenkova (champion)

• # 🇸🇰 Dominika Cibulková (semifinals)

• # 🇭🇺 Ágnes Szávay (quarterfinals)

• # 🇪🇸 Anabel Medina Garrigues (first round)

• # 🇨🇦 Aleksandra Wozniak (second round)

• # 🇨🇿 Lucie Šafářová (first round)