2010 Mutua Madrileña Madrid Open – Men's singles

Rafael Nadal defeated the defending champion Roger Federer in a rematch of the previous year's final, 6–4, 7–6(7–5) to win the men's singles tennis title at the 2010 Madrid Open.

Seeds
The top eight seeds receive a bye into the second round. • # Roger Federer (final)

• # 🇪🇸 Rafael Nadal (champion)

• # 🇬🇧 Andy Murray (quarterfinals)

• # 🇸🇪 Robin Söderling (second round)

• # 🇺🇸 Andy Roddick (withdrew due to stomach virus)

• # 🇪🇸 Fernando Verdasco (third round)

• # 🇫🇷 Jo-Wilfried Tsonga (second round, retired due to back injury)

• # Marin Čilić (third round)

• # 🇪🇸 David Ferrer (semifinals)

• # 🇷🇺 Mikhail Youzhny (second round)

• # 🇨🇿 Tomáš Berdych (withdrew due to right hip injury)

• # 🇫🇷 Gaël Monfils (quarterfinals)

• # 🇺🇸 John Isner (third round)

• # 🇺🇸 Sam Querrey (first round)

• # Stanislas Wawrinka (third round)

• # 🇧🇷 Thomaz Bellucci (second round)

Seeds
• # 🇦🇷 Juan Ignacio Chela (qualified)

• # 🇦🇷 Eduardo Schwank (withdrew)

• # 🇨🇴 Santiago Giraldo (qualified)

• # 🇺🇦 Alexandr Dolgopolov (qualified)

• # 🇨🇴 Alejandro Falla (first round)

• # 🇺🇸 Michael Russell (qualifying competition, retired due to wrist injury, lucky loser)

• # Kevin Anderson (qualified)

• # 🇺🇸 Mardy Fish (qualifying competition, lucky loser)

• # 🇪🇸 Daniel Gimeno Traver (qualified)

• # 🇪🇸 Óscar Hernández (qualifying competition, lucky loser)

• # 🇪🇸 Iván Navarro (qualifying competition)

• # 🇮🇹 Filippo Volandri (qualifying competition)

• # Ilija Bozoljac (first round)

• # 🇧🇷 João Souza (first round)

Qualifiers
• # 🇦🇷 Juan Ignacio Chela

• # 🇪🇸 Daniel Muñoz de la Nava

• # 🇨🇴 Santiago Giraldo

• # 🇺🇦 Alexandr Dolgopolov

• # 🇧🇪 Christophe Rochus

• # 🇪🇸 Daniel Gimeno Traver

• # Kevin Anderson

Lucky losers
• # 🇺🇸 Michael Russell

• # 🇺🇸 Mardy Fish

• # 🇪🇸 Óscar Hernández