2010 Mutua Madrileña Madrid Open – Women's doubles

Cara Black and Liezel Huber were the defending champions, but they chose not to compete together.

Black partnered up with Elena Vesnina, but they lost to Chan Yung-jan and Zheng Jie in the first round.

Huber teamed with Anabel Medina Garrigues, but they lost to Chuang Chia-jung and Vania King in the second round.

Venus and Serena Williams won in the final 6–2, 7–5 against Gisela Dulko and Flavia Pennetta.

Seeds
The top four seeds received a bye into the second round. • # 🇺🇸 Serena Williams / 🇺🇸 Venus Williams (champions)

• # 🇪🇸 Nuria Llagostera Vives / 🇪🇸 María José Martínez Sánchez (semifinals)

• # 🇷🇺 Nadia Petrova / 🇦🇺 Samantha Stosur (second round)

• # 🇺🇸 Liezel Huber / 🇪🇸 Anabel Medina Garrigues (second round)

• # Cara Black / 🇷🇺 Elena Vesnina (first round)

• # 🇺🇸 Lisa Raymond / 🇦🇺 Rennae Stubbs (second round)

• # 🇺🇸 Bethanie Mattek-Sands / 🇨🇳 Yan Zi (second round)

• # 🇦🇷 Gisela Dulko / 🇮🇹 Flavia Pennetta (final)