2010 NCAA Division II women's basketball tournament

The 2010 NCAA Division II women's basketball tournament was the 29th annual tournament hosted by the NCAA to determine the national champion of Division II women's collegiate basketball in the United States.

Emporia State defeated Fort Lewis in the championship game, 65–53, to claim the Lady Hornets' first NCAA Division II national title.

The championship rounds were contested at the St. Joseph Civic Arena in St. Joseph, Missouri.

Atlantic - California and Erie, Pennsylvania
^ California, Pennsylvania Location: Hamer Hall Host: California University of Pennsylvania

~ Erie, Pennsylvania Location: Hammermill Center Host: Gannon University

Southeast - Greenwood, South Carolina
Location: Horne Arena Host: Lander University

South Central - Canyon, Texas
Location: First United Bank Center Host: West Texas A&M University

Midwest - Houghton, Michigan
Location: SDC Gymnasium Host: Michigan Technological University

East - Fitchburg, Massachusetts
Location: Fitchburg State Recreation Center Host: Franklin Pierce College

South - Russellville, Arkansas
Location: Tucker Coliseum Host: Arkansas Tech University

Central - Durango, Colorado
Location: Whalen Gymnasium Host: Fort Lewis College

West - Seattle, Washington
Location: Royal Brougham Pavilion Host: Seattle Pacific University

Elite Eight - St. Joseph, Missouri
Location: St. Joseph Civic Arena Host: Missouri Western State University

All-tournament team

 * Alli Volkens, Emporia State
 * Cassondra Boston, Emporia State
 * Brittney Miller, Emporia State
 * Laura Haugen, Fort Lewis
 * Allison Rosel, Fort Lewis