2010 Natomas Men's Professional Tennis Tournament – Singles

Santiago Giraldo was the defending champion, but decided not to participate this year.

John Millman defeated 5th seed Robert Kendrick 6–3, 6–2 in the final match.

Seeds
• # 🇩🇪 Tobias Kamke (second round)

• # 🇺🇸 Donald Young (second round)

• # 🇩🇪 Julian Reister (second round)

• # 🇺🇸 Ryan Sweeting (quarterfinals)

• # 🇺🇸 Robert Kendrick (final)

• # 🇦🇺 Carsten Ball (second round)

• # Izak van der Merwe (first round)

• # 🇺🇸 Kevin Kim (second round)