2010 Northwestern State Demons football team

The 2010 Northwestern State Demons football team represented Northwestern State University as a member of the Southland Conference during the 2010 NCAA Division I FCS football season. Led by second-year head coach Bradley Dale Peveto, the Demons compiled an overall record of 5–6 with a mark of 4–3 in conference play, placing in a three-way tie for third in the Southland. Northwestern State played home games at Harry Turpin Stadium in Natchitoches, Louisiana.