2010 Odlum Brown Vancouver Open – Men's singles

Marcos Baghdatis was the defending champion, but chose to compete in ATP 500 in Washington instead. Dudi Sela won the title, defeating Ričardas Berankis 7–5, 6–2 in the finals.

Seeds
• # 🇺🇸 Taylor Dent (semifinals)

• # 🇩🇪 Tobias Kamke (second round)

• # 🇮🇱 Dudi Sela (champion)

• # 🇱🇹 Ričardas Berankis (final)

• # 🇷🇸 Ilija Bozoljac (first round)

• # 🇺🇸 Jesse Levine (quarterfinals)

• # 🇺🇸 Robert Kendrick (second round)

• # 🇺🇸 Jesse Witten (first round)