2010 Open Barletta – Singles

Ivo Minář was the defending champion, however he lost to Pere Riba in the first round.

Pere Riba won in the final 6–3 (and retirement), against Steve Darcis.

Seeds
• # 🇫🇮 Jarkko Nieminen (quarterfinals)

• # 🇪🇸 Santiago Ventura (first round)

• # 🇧🇪 Steve Darcis (final)

• # Blaž Kavčič (quarterfinals)

• # 🇷🇺 Igor Kunitsyn (quarterfinals)

• # 🇪🇸 Pere Riba (champion)

• # 🇪🇸 Iván Navarro (first round)

• # 🇮🇹 Simone Bolelli (semifinals)