2010 Open Castilla y León – Singles

Feliciano López won the previous year's edition, but decided not to participate in 2010.

Daniel Gimeno Traver defeated Adrian Mannarino 6–4, 7–6(2) in the final.

Seeds
• # 🇪🇸 Daniel Gimeno Traver (champion)

• # 🇪🇸 Marcel Granollers (first round)

• # 🇪🇸 Rubén Ramírez Hidalgo (first round)

• # Stéphane Bohli (second round)

• # 🇧🇷 Thiago Alves (second round)

• # 🇫🇷 Marc Gicquel (first round)

• # 🇪🇸 Iván Navarro (second round)

• # Ivan Dodig (first round)