2010 Open GDF Suez – Singles

Amélie Mauresmo was the defending champion, but she retired from the sport on 3 December 2009.

Elena Dementieva won the title, defeating Lucie Šafářová in the final 6–7(5–7), 6–1, 6–4. This was Dementieva's final WTA singles title, before her retirement at the end of 2010.

Seeds
The top two seeds received a bye into the second round. • # 🇷🇺 Elena Dementieva (champion)

• # 🇮🇹 Flavia Pennetta (semifinals)

• # 🇧🇪 Yanina Wickmayer (first round)

• # 🇮🇹 Francesca Schiavone (second round)

• # 🇫🇷 Aravane Rezaï (second round)

• # 🇮🇱 Shahar Pe'er (quarterfinals)

• # 🇫🇷 Virginie Razzano (first round)

• # 🇷🇺 Elena Vesnina (second round)