2010 Pilot Pen Tennis – Women's singles

Caroline Wozniacki was the defending champion for the second year running, and once again won in the final 6–3, 3–6, 6–3 against Nadia Petrova to clinch her third straight New Haven crown.

Seeds
The top two seeds receive a bye into the second round. • # Caroline Wozniacki (champion)

• # 🇦🇺 Samantha Stosur (quarterfinals)

• # 🇮🇹 Francesca Schiavone (first round)

• # 🇷🇺 Elena Dementieva (semifinals)

• # 🇧🇪 Yanina Wickmayer (first round)

• # 🇫🇷 Marion Bartoli (quarterfinals)

• # 🇮🇹 Flavia Pennetta (quarterfinals, withdrew due to right foot injury)

• # 🇷🇺 Nadia Petrova (final)