2010 Prairie View A&M Panthers football team

The 2010 Prairie View A&M Panthers football team represented Prairie View A&M University as a member of the Southwestern Athletic Conference (SWAC) during the 2010 NCAA Division I FCS football season. Led by seventh-year head coach Henry Frazier III, the Panthers compiled an overall record of 7–4 and a mark of 6–3 in conference play, and finished second in the SWAC West Division.