2010 Regional League Division 2 Central & Eastern Region

2010 Regional League Division 2 Central & Eastern Region is the 2nd season of the League competition since its establishment in 2009. It is in the third tier of the Thai football league system.

The league has been expanded from 12 clubs in 2009 to 16 clubs this season. The league winners and runners up will qualify for the 2010 Regional League Division 2 championship stage.

Relocated clubs

 * Thai Summit Samut Prakan and Rose Asia Pathum Thani re-located to the Regional League Bangkok Area Division 2010.
 * Prachuap Khiri Khan re-located to the Regional League Southern Region 2010

Expansion clubs
Samut Sakhon, Muangkan, Phetchaburi, Ang Thong, Sa Kaeo, Prachinburi United, Pathum Thani and Kabinburi joined the newly expanded league setup.