2010 Regional League Division 2 Northern Region

2010 Regional League Division 2 Northern Region is the second season of the League competition since its establishment in 2009. It is in the third tier of the Thai football league system.

The league has been expanded from 11 clubs in 2009 to 16 clubs this season. The league winners and runners up will qualify for the 2010 Regional League Division 2 championship stage.

Promoted clubs
Chiangrai United were promoted to the 2010 Thai Division 1 League after coming 2nd in the 2009 Regional League Division 2 championship pool.

Relegated clubs
Nakhon Sawan were relegated from the 2009 Thai Division 1 League after finishing the season in 16th place.

Renamed clubs
Phrae renamed Phrae United Chiangmai United renamed Chiangmai

Expansion clubs
Chiangrai, Lampang, Phayao and Uthai Thani joined the newly expanded league setup.