2010 Regions Morgan Keegan Championships – Doubles

Mardy Fish and Mark Knowles were the defending champions; however, they decided to retire their match against John Isner and Sam Querrey, when result of this match was 6–3, 5–7. Isner and Querrey won in the final 6–4, 6–4, against Ross Hutchins and Jordan Kerr.

Seeds
• # 🇮🇳 Mahesh Bhupathi / 🇧🇾 Max Mirnyi (first round)

• # 🇺🇸 Mardy Fish / Mark Knowles (semifinals, retired)

• # 🇧🇷 Marcelo Melo / 🇧🇷 Bruno Soares (first round)

• # 🇨🇿 Martin Damm / 🇸🇰 Filip Polášek (first round)