2010 Regions Morgan Keegan Championships – Singles

Andy Roddick was the defending champion, but lost in the quarterfinals to Sam Querrey.

Sam Querrey won in the final 6–7(3–7), 7–6(7–5), 6–3, against John Isner.

Seeds
• # 🇺🇸 Andy Roddick (quarterfinals)

• # 🇪🇸 Fernando Verdasco (first round)

• # 🇨🇿 Radek Štěpánek (second round)

• # 🇩🇪 Tommy Haas (first round)

• # 🇨🇿 Tomáš Berdych (quarterfinals)

• # 🇺🇸 John Isner (final)

• # 🇩🇪 Philipp Kohlschreiber (first round)

• # 🇺🇸 Sam Querrey (champion)

Seeds
• # 🇨🇴 Santiago Giraldo (first round)

• # 🇷🇺 Teymuraz Gabashvili (first round)

• # 🇺🇸 Kevin Kim (qualifying competition)

• # 🇨🇦 Jesse Levine (qualifying competition, retired)

• # Kevin Anderson (qualified)

• # 🇺🇸 Robert Kendrick (qualified)

• # 🇺🇸 Michael Yani (first round)

• # Paul Capdeville (first round)

Qualifiers
• # 🇺🇸 Ryan Sweeting

• # Kevin Anderson

• # 🇺🇸 Robert Kendrick

• # 🇺🇸 Ryan Harrison