2010 Rogers Cup – Men's singles

Defending champion Andy Murray defeated Roger Federer in the final, 7–5, 7–5 to win the men's singles tennis title at the 2010 Canadian Open. Murray became the first player since Andre Agassi in 1995 to defend the title. It was also the first time in the tournament's history that the top four seeds (in this case the Big Four) reached the semifinals.

Seeds
The top eight seeds receive a bye into the second round. • # 🇪🇸 Rafael Nadal (semifinals)

• # 🇷🇸 Novak Djokovic (semifinals)

• # Roger Federer (final)

• # 🇬🇧 Andy Murray (champion)

• # 🇸🇪 Robin Söderling (third round)

• # 🇷🇺 Nikolay Davydenko (third round)

• # 🇨🇿 Tomáš Berdych (quarterfinals)

• # 🇺🇸 Andy Roddick (withdrew due to glandular fever)

• # 🇪🇸 Fernando Verdasco (second round)

• # 🇪🇸 David Ferrer (first round)

• # Marin Čilić (first round)

• # 🇷🇺 Mikhail Youzhny (second round)

• # 🇦🇹 Jürgen Melzer (first round)

• # 🇪🇸 Nicolás Almagro (second round)

• # 🇫🇷 Gaël Monfils (third round)

• # 🇺🇸 Sam Querrey (second round)