2010 SA Tennis Open – Singles

Jo-Wilfried Tsonga was the defending champion, but he resigned from the participation in this tournament due to tiredness caused by his performance at the 2010 Australian Open (he reached the semifinals, where he lost to Roger Federer).

Feliciano López won in the final 7–5, 6–1 against Stéphane Robert. It was López's second title of his career, and first since 2004.

Seeds
• # 🇫🇷 Gaël Monfils (semifinals)

• # 🇪🇸 David Ferrer (semifinals)

• # 🇪🇸 Feliciano López (champion)

• # Marco Chiudinelli (first round)

• # 🇺🇸 Rajeev Ram (quarterfinals)

• # 🇧🇪 Xavier Malisse (first round)

• # Lu Yen-hsun (quarterfinals)

• # 🇫🇷 Stéphane Robert (final)

Qualifying
All seeded players received a bye into the second round, and all players playing in the fourth qualifier received a bye into the second round.

Seeds
• # 🇫🇷 Édouard Roger-Vasselin (qualifying competition)

• # 🇦🇹 Andreas Haider-Maurer (qualifying competition)

• # 🇮🇳 Prakash Amritraj (second round)

• # Benjamin Balleret (qualified)

• # 🇮🇱 Noam Okun (qualified)

• # 🇸🇪 Filip Prpic (qualified)

• # Alexander Sadecky (qualifying competition)

• # Fritz Wolmarans (qualified)

Qualifiers
• # Fritz Wolmarans

• # 🇸🇪 Filip Prpic

• # 🇮🇱 Noam Okun

• # Benjamin Balleret