2010 Serbia Open – Singles

Sam Querrey defeated John Isner in the final, 3–6, 7–6(7–4), 6–4 to win the singles tennis title at the 2010 Serbia Open.

Novak Djokovic was the defending champion, but retired in the quarterfinals against Filip Krajinović.

Seeds
The first four seeds gets a first-round bye. • # 🇷🇸 Novak Djokovic (quarterfinals, retired due to breathing problems)

• # 🇺🇸 John Isner (final)

• # 🇺🇸 Sam Querrey (champion)

• # Stanislas Wawrinka (semifinals)

• # Ivo Karlović (second round)

• # 🇷🇸 Viktor Troicki (quarterfinals)

• # 🇷🇸 Janko Tipsarević (withdrew, illness)

• # 🇮🇹 Andreas Seppi (second round)