2010 Sony Ericsson Open – Men's singles

Andy Roddick defeated Tomáš Berdych in the final, 7–5, 6–4 to win the men's singles tennis title at the 2010 Miami Open. It was his first Masters title since 2006, and his second career Miami Open title.

Andy Murray was the defending champion, but lost to Mardy Fish in the second round.

Seeds
All seeds receive a bye into the second round. • # Roger Federer (fourth round)

• # 🇷🇸 Novak Djokovic (second round)

• # 🇬🇧 Andy Murray (second round)

• # 🇪🇸 Rafael Nadal (semifinals)

• # 🇸🇪 Robin Söderling (semifinals)

• # 🇺🇸 Andy Roddick (champion)

• # Marin Čilić (fourth round)

• # 🇫🇷 Jo-Wilfried Tsonga (quarterfinals)

• # Fernando González (fourth round)

• # 🇪🇸 Fernando Verdasco (quarterfinals)

• # Ivan Ljubičić (second round, retired due to back injury)

• # 🇪🇸 Juan Carlos Ferrero (fourth round)

• # 🇷🇺 Mikhail Youzhny (quarterfinals)

• # 🇫🇷 Gaël Monfils (withdrew due to left wrist injury)

• # 🇪🇸 David Ferrer (fourth round)

• # 🇨🇿 Tomáš Berdych (final)

• # 🇺🇸 John Isner (third round)

• # 🇪🇸 Tommy Robredo (third round)

• # Stanislas Wawrinka (third round)

• # 🇫🇷 Gilles Simon (second round)

• # 🇺🇸 Sam Querrey (second round)

• # 🇦🇷 Juan Mónaco (third round)

• # 🇦🇹 Jürgen Melzer (third round)

• # Ivo Karlović (third round)

• # 🇨🇾 Marcos Baghdatis (third round)

• # 🇪🇸 Albert Montañés (second round)

• # 🇧🇷 Thomaz Bellucci (fourth round)

• # 🇩🇪 Philipp Kohlschreiber (third round)

• # 🇪🇸 Feliciano López (third round)

• # 🇷🇸 Viktor Troicki (second round)

• # 🇷🇸 Janko Tipsarević (second round)

• # 🇫🇷 Julien Benneteau (second round)

• # 🇪🇸 Nicolás Almagro (quarterfinals)

Seeds
• # 🇺🇿 Denis Istomin (qualified)

• # 🇩🇪 Mischa Zverev (first round)

• # 🇺🇦 Illya Marchenko (qualified)

• # 🇧🇷 Marcos Daniel (qualifying competition, lucky loser)

• # 🇧🇪 Xavier Malisse (qualified)

• # Nicolás Massú (qualified)

• # 🇩🇪 Rainer Schüttler (qualified)

• # 🇪🇨 Nicolás Lapentti (qualifying competition, lucky loser)

• # 🇨🇴 Santiago Giraldo (qualified)

• # 🇰🇿 Andrey Golubev (qualified)

• # 🇺🇸 Wayne Odesnik (first round)

• # Lu Yen-hsun (qualified)

• # Fred Gil (first round)

• # 🇺🇸 Robby Ginepri (first round)

• # 🇧🇷 Ricardo Mello (qualified)

• # 🇩🇪 Björn Phau (first round)

• # 🇨🇦 Jesse Levine (qualifying competition)

• # 🇫🇷 Josselin Ouanna (first round)

• # Rui Machado (first round)

• # 🇮🇳 Somdev Devvarman (qualifying competition)

• # 🇹🇷 Marsel İlhan (qualified)

• # 🇯🇲 Dustin Brown (first round)

• # 🇺🇸 Kevin Kim (qualifying competition)

• # Kevin Anderson (qualified)

Qualifiers
• # 🇺🇿 Denis Istomin

• # Kevin Anderson

• # 🇺🇦 Illya Marchenko

• # 🇹🇷 Marsel İlhan

• # 🇧🇪 Xavier Malisse

• # Nicolás Massú

• # 🇩🇪 Rainer Schüttler

• # 🇧🇷 Ricardo Mello

• # 🇨🇴 Santiago Giraldo

• # 🇰🇿 Andrey Golubev

• # 🇺🇸 Ryan Sweeting

• # Lu Yen-hsun

Lucky losers
• # 🇧🇷 Marcos Daniel

• # 🇪🇨 Nicolás Lapentti