2010 Soweto Open – Singles

Fabrice Santoro was the defending champion, but chose not to compete this year. Dustin Brown won in the final 7–6(7–2), 6–3 against Izak van der Merwe.

Seeds
• # 🇸🇰 Lukáš Lacko (first round)

• # 🇸🇰 Karol Beck (first round)

• # Lu Yen-hsun (first round)

• # 🇮🇱 Harel Levy (second round)

• # 🇯🇲 Dustin Brown (champion)

• # Stéphane Bohli (semifinals)

• # Grega Žemlja (first round)

• # Igor Sijsling (first round)