2010 St. Petersburg Open – Singles

Sergiy Stakhovsky was the defending champion, but lost in the first round to Benjamin Becker. Mikhail Kukushkin defeated 1st seed Mikhail Youzhny 6–3, 7–6(7–2) to win this tournament.

Seeds
• # 🇷🇺 Mikhail Youzhny (final)

• # 🇺🇦 Sergiy Stakhovsky (first round)

• # 🇷🇸 Janko Tipsarević (quarterfinals)

• # Lu Yen-hsun (second round)

• # 🇷🇸 Viktor Troicki (first round)

• # 🇺🇿 Denis Istomin (first round, retired because of a right knee injury)

• # 🇫🇷 Jérémy Chardy (first round)

• # 🇷🇴 Victor Hănescu (quarterfinals)