2010 Status Athens Open – Singles

Rui Machado was the defending champion, but chose to compete in Rome instead.

Lu Yen-hsun won in the final 3–6, 7–6(7–4), 6–4, against Rainer Schüttler.

Seeds
• # 🇩🇪 Benjamin Becker (first round)

• # 🇩🇪 Philipp Petzschner (second round, retired)

• # Marco Chiudinelli (quarterfinals)

• # 🇸🇰 Lukáš Lacko (second round)

• # 🇮🇱 Dudi Sela (semifinals)

• # 🇧🇪 Xavier Malisse (first round)

• # 🇩🇪 Rainer Schüttler (final)

• # Lu Yen-hsun (champion)