2010 Swiss Indoors – Singles

Novak Djokovic was the defending champion, but lost to Roger Federer 6–4, 3–6, 6–1 in the final.

Seeds
• # Roger Federer (champion)

• # 🇷🇸 Novak Djokovic (final)

• # 🇨🇿 Tomáš Berdych (first round)

• # 🇺🇸 Andy Roddick (semifinals)

• # 🇦🇹 Jürgen Melzer (withdrew due to fatigue)

• # Marin Čilić (second round)

• # Ivan Ljubičić (withdrew due to fatigue)

• # 🇺🇸 John Isner (second round)

Seeds
• # 🇫🇮 Jarkko Nieminen (qualified)

• # Robin Haase (qualified)

• # 🇩🇪 Tobias Kamke (qualifying competition, lucky loser)

• # 🇩🇪 Daniel Brands (qualified)

• # 🇸🇰 Lukáš Lacko (first round)

• # 🇸🇰 Karol Beck (qualifying competition, lucky loser)

• # 🇨🇿 Jan Hájek (qualified)

• # 🇫🇷 Paul-Henri Mathieu (qualifying competition, lucky loser)

Qualifiers
• # 🇫🇮 Jarkko Nieminen

• # Robin Haase

• # 🇨🇿 Jan Hájek

• # 🇩🇪 Daniel Brands

Lucky losers
• # 🇩🇪 Tobias Kamke

• # 🇸🇰 Karol Beck

• # 🇫🇷 Paul-Henri Mathieu