2010 Tashkent Open – Singles

Shahar Pe'er was the defending champion, but chose not to participate that year. Alla Kudryavtseva won in the final, 6–4, 6–4, against Elena Vesnina.

Seeds
• # 🇷🇴 Alexandra Dulgheru (quarterfinals)

• # 🇺🇿 Akgul Amanmuradova (quarterfinals)

• # 🇷🇺 Anna Chakvetadze (second round, retired due to viral disease)

• # 🇷🇺 Elena Vesnina (final)

• # 🇷🇴 Monica Niculescu (semifinals)

• # 🇸🇰 Magdaléna Rybáriková (second round)

• # 🇷🇺 Alla Kudryavtseva (champion)

• # 🇮🇹 Maria Elena Camerin (second round)