2010 U.S. Men's Clay Court Championships

The 2010 U.S. Men's Clay Court Championships was a men's tennis tournament played on outdoor clay courts. It was the 42nd edition of the U.S. Men's Clay Court Championships, and was an ATP World Tour 250 event. It took place at River Oaks Country Club in Houston, Texas, United States, from April 5 through April 11, 2010. Unseeded Juan Ignacio Chela won the singles title.

Seeds

 * Rankings and seedings are as of March 22.

Other entrants
The following players received wildcards into the main draw:
 * 🇦🇺 Lleyton Hewitt
 * 🇵🇱 Jerzy Janowicz
 * 🇺🇸 Donald Young

The following players received entry via qualifying:
 * Kevin Anderson
 * 🇦🇺 Nick Lindahl
 * 🇮🇪 Conor Niland
 * 🇺🇸 Ryan Sweeting

Singles
🇦🇷 Juan Ignacio Chela defeated 🇺🇸 Sam Querrey, 5–7, 6–4, 6–3
 * It was Chela's first title of the year and 5th of his career.

Doubles
🇺🇸 Bob Bryan / 🇺🇸 Mike Bryan defeated 🇦🇺 Stephen Huss / Wesley Moodie, 6–3, 7–5