2010 U.S. Men's Clay Court Championships – Singles

Lleyton Hewitt was the defending champion, but he lost to Juan Ignacio Chela in the quarterfinals. Chela won in the final 5–7, 6–4, 6–3 against Sam Querrey.

Seeds
The top four seeds receive a bye into the second round. • # Fernando González (quarterfinals)

• # 🇺🇸 John Isner (second round)

• # 🇺🇸 Sam Querrey (final)

• # 🇦🇺 Lleyton Hewitt (quarterfinals)

• # 🇰🇿 Evgeny Korolev (first round)

• # 🇦🇷 Horacio Zeballos (semifinals)

• # 🇦🇷 Eduardo Schwank (second round)

• # 🇺🇸 Michael Russell (withdrew due to leg injury)

Seeds
• # Kevin Anderson (qualified)

• # 🇮🇳 Somdev Devvarman (qualifying competition, lucky loser)

• # 🇺🇸 Michael Yani (qualifying competition, lucky loser)

• # Paul Capdeville (second round)

• # 🇺🇸 Ryan Sweeting (qualified)

• # 🇦🇷 Juan Pablo Brzezicki (first round)

• # 🇺🇸 Alex Kuznetsov (qualifying competition)

• # 🇦🇺 Greg Jones (second round)

Qualifiers
• # Kevin Anderson

• # 🇦🇺 Nick Lindahl

• # 🇺🇸 Ryan Sweeting

• # 🇮🇪 Conor Niland

Lucky losers
• # 🇮🇳 Somdev Devvarman

• # 🇺🇸 Michael Yani