2010 USTA Challenger of Oklahoma – Singles

Taylor Dent was the champion in 2009, but he retired in the first round match, against Oleksandr Nedovyesov due to fatigue. Bobby Reynolds won the title after defeating Lester Cook in the final 6–3, 6–3.

Seeds
• # 🇺🇸 Taylor Dent (first round, retired due to fatigue)

• # 🇺🇸 Donald Young (first round)

• # 🇺🇸 Kevin Kim (quarterfinals, retired)

• # 🇺🇸 Jesse Levine (first round)

• # 🇺🇸 Jesse Witten (quarterfinals)

• # 🇺🇸 Tim Smyczek (semifinals)

• # 🇺🇸 Lester Cook (final)

• # 🇺🇸 Michael Yani (second round)