2010 US Open – Wheelchair men's singles

Two-time defending champion Shingo Kunieda won the men's singles wheelchair tennis title at the 2010 US Open after Nicolas Peifer withdrew before the final. It was his third US Open singles title and eleventh major singles title overall.

Seeds

 * 1) 🇯🇵 Shingo Kunieda (champion)
 * 2) Maikel Scheffers (semifinals)