2010 Western & Southern Financial Group Masters – Singles

Defending champion Roger Federer defeated Mardy Fish in the final, 6–7(5–7), 7–6(7–1), 6–4 to win the men's singles tennis title at the 2010 Cincinnati Masters. It was his fourth Cincinnati Masters title, his record-equaling 17th Masters title overall (tying Andre Agassi's tally), and his 63rd career title overall (tying Björn Borg's tally).

Seeds
The top eight seeds receive a bye into the second round. • # 🇪🇸 Rafael Nadal (quarterfinals)

• # 🇷🇸 Novak Djokovic (quarterfinals)

• # Roger Federer (champion)

• # 🇬🇧 Andy Murray (quarterfinals)

• # 🇸🇪 Robin Söderling (third round)

• # 🇷🇺 Nikolay Davydenko (quarterfinals)

• # 🇨🇿 Tomáš Berdych (third round)

• # 🇪🇸 Fernando Verdasco (second round)

• # 🇺🇸 Andy Roddick (semifinals)

• # 🇪🇸 David Ferrer (third round)

• # Marin Čilić (first round)

• # 🇷🇺 Mikhail Youzhny (first round)

• # 🇦🇹 Jürgen Melzer (second round)

• # 🇪🇸 Nicolás Almagro (first round)

• # Ivan Ljubičić (first round)

• # 🇫🇷 Gaël Monfils (first round)

Seeds
• # 🇰🇿 Andrey Golubev (first round, retired)

• # 🇩🇪 Florian Mayer (qualified)

• # 🇺🇿 Denis Istomin (qualified)

• # 🇨🇴 Santiago Giraldo (qualified)

• # 🇫🇮 Jarkko Nieminen (qualifying competition)

• # 🇨🇴 Alejandro Falla (qualified)

• # Marco Chiudinelli (first round)

• # 🇫🇷 Florent Serra (qualifying competition)

• # 🇺🇦 Illya Marchenko (first round)

• # 🇩🇪 Benjamin Becker (qualified)

• # 🇫🇷 Arnaud Clément (qualifying competition)

• # 🇩🇪 Simon Greul (qualifying competition)

• # 🇺🇸 Taylor Dent (qualified)

• # 🇺🇸 Michael Russell (qualifying competition)

Qualifiers
• # 🇩🇪 Benjamin Becker

• # 🇩🇪 Florian Mayer

• # 🇺🇿 Denis Istomin

• # 🇨🇴 Santiago Giraldo

• # 🇺🇸 Taylor Dent

• # 🇨🇴 Alejandro Falla

• # 🇮🇳 Somdev Devvarman