2010 Western & Southern Financial Group Women's Open – Doubles

Cara Black and Liezel Huber were the defending champions. Both were present that year, but chose to compete with different players.

Black partnered with Anastasia Rodionova but lost 6–4, 6–4 in quarterfinals against Gisela Dulko and Flavia Pennetta. Huber partnered with Nadia Petrova but lost 7–5, 6–2 in semifinals against Lisa Raymond and Rennae Stubbs. Victoria Azarenka and Maria Kirilenko won 7–6(7–4), 7–6(7–8) in the final against Lisa Raymond and Rennae Stubbs.

Seeds
The top four seeds receive a bye into the second round. • # 🇺🇸 Liezel Huber / 🇷🇺 Nadia Petrova (semifinals)

• # 🇦🇷 Gisela Dulko / 🇮🇹 Flavia Pennetta (semifinals)

• # 🇨🇿 Květa Peschke / 🇸🇮 Katarina Srebotnik (second round)

• # 🇺🇸 Lisa Raymond / 🇦🇺 Rennae Stubbs (final)

• # 🇺🇸 Vania King / 🇰🇿 Yaroslava Shvedova (second round)

• # 🇷🇺 Alisa Kleybanova / 🇷🇺 Ekaterina Makarova (first round)

• # Chan Yung-jan / 🇨🇳 Zheng Jie (quarterfinals)

• # Cara Black / 🇦🇺 Anastasia Rodionova (quarterfinals)