2011 Campbell's Hall of Fame Tennis Championships – Singles

Mardy Fish was the defending champion, but decided to participate in the Davis Cup instead.

No. 1 seed John Isner won the tournament, beating Belgian Olivier Rochus in the final, 6–3, 7–6(8–6). In doing so, Isner became the first top seed to ever win the tournament, breaking the "Casino Curse."

Seeds
• # 🇺🇸 John Isner (champion)

• # 🇧🇬 Grigor Dimitrov (second round)

• # 🇷🇺 Igor Kunitsyn (first round)

• # 🇺🇸 Ryan Sweeting (first round)

• # 🇺🇸 Alex Bogomolov Jr. (quarterfinals)

• # 🇧🇪 Olivier Rochus (final)

• # 🇩🇪 Michael Berrer (first round)

• # 🇩🇪 Tobias Kamke (semifinals)